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The story begins when high school student Kazuki Muto is killed one night saving a mysterious girl from a monster, only to wake up in his school dorm, believing it to have been a dream; however, he soon finds out that dream wasn't a dream at all when a giant serpentine monster attacks him and his sister. Tokiko Tsumura, the girl he saved, explains that the monster is a homunculus. Kazuki had been attacked and killed by it when he was rescuing her; however, she, feeling responsible for him, revived him by placing a Kakugane medallion in his chest, serving as a replacement heart.
As a prophecy of doom unfolds on the peaceful land of Britannia, a purehearted boy sets out on a journey of discovery — and revenge.
It is August 12th. After the remote control to his boarding house's only air conditioning unit is inadvertently destroyed by spilled cola, "I" devises a plan to return to yesterday in a time machine to recover the remote before it breaks. However, his prankster friend Ozu cannot resist playing with past events, even if it means bringing the universe to the brink of destruction. Now "I" finds himself racing through time to avoid disaster.
In a distant future, Tetsuro is a human boy who wants his body replaced with a robotic one. This is possible, but to do so he has to reach the Immortal Planet onboard the space train Galaxy Express 999. Maetel, a beautiful and mysterious blonde woman dressed in Russian style, joins him in the long journey through space. Every episode sees our heroes arriving in a new planet's space train station.
The swordsmith Amon accidentally comes across an infant and its dead mother in the forest. Although he is initially overwhelmed by the situation, he finally decides to take the boy with him and thus save him from certain death. Ten years after this fateful encounter, the boy from that time, Gai, is apprenticed to Amon. While making a sword, however, there is a tragic accident in which Gai loses his right arm. Amon then decides to use a sword called Shiryuu to make an artificial arm for Gai. Thus, it begins…
Accused of murder and thrown into the Pit, a young orphan joins a group of monster fighters with special powers to uncover the truth and seek vengeance.
